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Rosuvastatin is used for lowering high cholesterol and triglycerides in certain patients.

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Cost of doxycycline hyclate 20 mg /mL (R01CA090783) and placebo. The 2 groups were matched for demographic characteristics (age, sex, and race/ethnicity). Patients who received doxycycline hyclate 20 mg/mL or placebo were also randomised to receive 1 of 3 doses ipilimumab (30 mg/mL, 50 or 70 mg/mL). During an additional 8 weeks, patients were switched to the other study drug or placebo. The primary endpoint was clinical response in the 1 year end of study after a single dose of doxycycline hyclate 20 mg/mL. The secondary endpoints were clinical response and persistence safety measures. The primary efficacy outcome of was clinical response by the end of study. Secondary endpoints are safety, serum lipid levels, laboratory measures, and a secondary endpoints review. Trial of Safety and Efficacy, the Phase 1b study that compared ipilimumab 60 mg/mL and doxycycline hyclate 20 mg/mL, was halted after 12 weeks of treatment because efficacy failure doxycycline hyclate 20 mg/mL relative to ipilimumab 30 mg/mL. Both trials would have been stopped at this point without the availability of a negative trial outcome. The main aim of trial Safety and Efficacy was a dose-ranging trial in both arms of patients with moderate to severe osteoarthritis. Trials of ipilimumab 60 mg/mL and doxycycline hyclate 20 Safety and efficacy of ipilimumab 60 mg/mL were assessed among adult patients with moderate to severe osteoarthritis and mild moderate chronic pain who met the following definitions: Major surgery or chronic musculoskeletal disease (n = 23) or cancer 5) Previous treatment with a corticosteroid (including erythromycin or tamsulosin) Pain >5 on a numerical rating scale (NRS) at baseline best drugstore brow gels and after 4 weeks treatment. Exclusion criteria were treatment with another corticosteroid and prior infection, or currently taking other pain drugs including nonsteroidal anti-inflammatory (NSAIDs). A minimum two-week course of oral doxycycline was also precluded. Intervention Patients began treatment with ipilimumab 60 mg/mL or doxycycline hyclate 20 mg/mL, which would be reduced to 10 mg/mL after 2 weeks of therapy. Trial of Safety and Efficacy was a phase 1b study in patients without previous treatment with a corticosteroid. Trial participants were randomised to receive either treatment before the first day of rest and with or without another pain-relieving medication, before and after 12 weeks of treatment, or no treatment. Patient participants were treated with either 1 mg/mL or 10 ipilimumab. Clinical response was defined as a ≥50% reduction in the most severe or pain score after 4 weeks of therapy. Pain scores and adverse events were recorded Existe generico de rosuvastatina at the beginning, week 6 (n = 12), and week 12 (n = 12). During each of the 12-week treatment, patients were switched to one of the other study drugs or placebo. Clinical response and safety endpoints were assessed at 4, 8, and 12 weeks of treatment. Serum levels total and lipoprotein-associated inflammatory biomarkers were measured during each of the 4 weeks pre-drug, pre-drug plus treatment (day 0), and post- drug 6). Efficacy Endpoint Primary efficacy was clinical response by end of treatment. Secondary efficacy endpoints were clinical response and stability. Safety Endpoint Secondary efficacy endpoints are safety measures during trial treatment. Adverse events were assessed at weekly intervals up to the last available observation before endpoint. Adverse events were recorded in all trial sites. The primary endpoint (clinical response) and secondary endpoints are the most frequently reported adverse events that were at least in part during the 12-week treatment period, most common reason for discontinuation of therapy at least 3 days, and the most common reason for discontinuation.

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